Description

Sildenafil (Viagra)

Product Overview

Sildenafil, commonly known by the brand name Viagra, is a selective phosphodiesterase type 5 (PDE5) inhibitor widely studied for its effects on vascular smooth muscle relaxation and blood flow regulation. It is used in clinical practice for specific approved indications and is also investigated in cardiovascular, pulmonary, and vascular physiology research. Sildenafil works by enhancing the nitric oxide (NO)-cGMP signaling pathway, promoting vasodilation in targeted tissues.

Key Features

  • Selective PDE5 inhibitor
  • High-purity pharmaceutical-grade compound
  • Well-characterized mechanism of action
  • Studied in cardiovascular and vascular research
  • Manufactured under strict quality standards
  • Available in multiple tablet strengths

How It Works

Sildenafil inhibits the phosphodiesterase type 5 (PDE5) enzyme, preventing the breakdown of cyclic guanosine monophosphate (cGMP). Increased cGMP levels promote relaxation of smooth muscle cells and improve blood flow in tissues where nitric oxide signaling is activated. Researchers study this mechanism to better understand vascular function, endothelial biology, and circulatory physiology.

Research Applications

Sildenafil is commonly studied in research involving:

  • Vascular biology
  • Nitric oxide (NO) signaling
  • PDE5 enzyme inhibition
  • Cardiovascular physiology
  • Pulmonary vascular research
  • Endothelial function
  • Smooth muscle pharmacology
  • Blood flow regulation
  • Molecular pharmacology
  • Clinical pharmacology

Specifications

Property Details
Product Name Sildenafil (Viagra)
Active Ingredient Sildenafil Citrate
Drug Class Phosphodiesterase Type 5 (PDE5) Inhibitor
Molecular Formula C22H30N6O4S
Molecular Weight 474.58 g/mol
Product Form Tablet
Research Category Cardiovascular & Vascular Research

Physical Properties

  • Appearance: Blue film-coated tablet (typical commercial formulation)
  • Purity: Pharmaceutical Grade
  • Dosage Form: Oral Tablet
  • Stability: Stable under recommended storage conditions

Storage Instructions

  • Store at room temperature (20–25°C).
  • Protect from excessive heat, moisture, and direct sunlight.
  • Keep tablets in the original packaging until use.
  • Store in a dry place.
  • Keep out of reach of children.

Packaging Information

Available packaging options may include:

  • 25 mg Tablets
  • 50 mg Tablets
  • 100 mg Tablets
  • Blister packs
  • Bottle packaging
  • Bulk packaging (where applicable)

Quality Assurance

Each production batch undergoes comprehensive quality testing for:

  • Identity verification
  • Active ingredient assay
  • Purity analysis
  • Dissolution testing
  • Stability evaluation
  • Batch-to-batch consistency

Precautions

  • Use only under the supervision of a qualified healthcare professional.
  • Not suitable for individuals taking nitrate medications due to the risk of severe hypotension.
  • Inform your healthcare provider about any cardiovascular conditions or other medications before use.
  • Keep out of reach of children.
  • Store according to the recommended conditions.

Shelf Life

Shelf life varies depending on the manufacturer and packaging. Refer to the product label for the expiration date and recommended storage conditions.

Frequently Asked Questions (FAQs)

What is Sildenafil?

Sildenafil is a selective PDE5 inhibitor that enhances nitric oxide-mediated vasodilation by increasing cGMP levels, improving blood flow in specific tissues.

What is Sildenafil commonly used for?

Sildenafil is approved in many countries for the treatment of erectile dysfunction (ED) and, in different formulations and doses, pulmonary arterial hypertension (PAH). It is also studied in cardiovascular and vascular physiology research.

How should Sildenafil be stored?

Store tablets at room temperature in a cool, dry place, protected from moisture and direct sunlight.

Is a Certificate of Analysis (COA) available?

Pharmaceutical manufacturers and research-grade suppliers may provide a Certificate of Analysis (COA) to verify product identity, purity, and quality.